An experienced ophthalmologist in Missouri, Dr. David D. Kim was instrumental in implementing an ophthalmology program at Prevea Health System in Wisconsin. An expert in ophthalmology, Dr. David D. Kim has written over 5 medical publications, including “Findings in Pseudoxanthoma Elasticum.”
A hereditary disorder, pseudoxanthoma elasticum (PXE) causes the elastic tissues in the body to lose their elastic properties. Elastic tissues are certain tissues, found in various parts of the body, with the ability to stretch up to 1.5 times their original length and return to their original length when relaxed. Pseudoxanthoma elasticum (PXE) primarily affects elastic tissues in the eyes, blood vessels, and skin. According to a report published in the Orphanet Journal of Rare Diseases, PXE has a slight female predominance.
In the eye, PXE causes an elastic fiber in the retina layer, called Bruch’s membrane, to lose elasticity. This loss of elasticity, accompanied by an increased deposit of calcium within the Bruch’s membrane, results in cracks. These cracks are called angioid streaks. Through the angioid streaks, abnormal blood vessels from the vascular layer below the retina sprout into the layers of the retina over time, causing thickening, swelling, and bleeding within the retina which gradually weakens vision.